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—In our article in the April issue of the Archives, we proposed that the gradient of fluorescein in the vitreous is a measure of the degree of transport of fluorescein across the vitreous gel. We suggest that a gradient lower than normal indicates more rapid transport of fluorescein in the vitreous, implying that the vitreous gel integrity has been compromised. We agree with Plehwe and Kohner that it would be interesting to exclude patients with a posterior vitreous detachment. Such an attempt was made in the following ways: (1) by examining the patients using simple slit-lamp biomicroscopy and excluding cases in which a posterior vitreous detachment could be observed (this point was inadvertently omitted in our article) and (2) by including mainly subjects who showed a fluorescein profile that declined monotonously from the posterior pole toward the midvitreous. The presence of such a profile probably rules out the
Ogura Y, Cunha-Vaz JG, Zeimer RC. Vitreous Fluorophotometry in Vitreous Degeneration-Reply. Arch Ophthalmol. 1987;105(8):1019–1020. doi:10.1001/archopht.1987.01060080017010