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October 1987

Immunohistopathology of Ocular Sarcoidosis: Report of a Case and Discussion of Immunopathogenesis

Author Affiliations

From the Laboratories of Immunology (Drs Chan, Wetzig, Palestine, and Nusenblatt) and Ophthalmic Pathology (Dr Kuwabara), National Eye Institute, National Institutes of Health, Bethesda, Md.

Arch Ophthalmol. 1987;105(10):1398-1402. doi:10.1001/archopht.1987.01060100100036

• An eye from a patient with systemic sarcoidosis and active ocular involvement was studied by the use of monoclonal antibodies and the immunoperoxidase technique to identify the subtypes of infiltrating cells and the presence of lymphokines. Large numbers of lymphoid cells reacting with anti-pan T cell (Leu-4) and anti-T helper/inducer (Leu-3a) subsets were observed around and within sarcoid granulomas. Only rare T suppressor cytotoxic cells (Leu-2a) were observed. B lymphocytes and plasma cells were present in a few foci. Within the granuloma, T lymphocytes, macrophages, and epithelioid cells showed membrane labeling for interleukin 2 receptors and interferon gamma. We demonstrate the in vivo expression of interleukin 2 receptors and the release of interferon gamma by mononuclear phagocytes and T lymphocytes in ocular sarcoidosis, and we theorize about the activated T helper cell-derived lymphokines in macrophage activation and sarcoid granuloma formation in the eye.