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November 1987

Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues: A Model Study

Author Affiliations

From the Howe Laboratory of Ophthalmology (Drs Kolodny, D'Amico, and Albert) and Retina Service (Drs Gragoudas, D'Amico, and Seddon), Massachusetts Eye and Ear Infirmary, Boston; Department of Ophthalmology, Harvard Medical School, Boston (Drs Kolodny, Gragoudas, D'Amico, Seddon, and Albert); Magnetic Resonance Imaging Facility, Massachusetts Institute of Technology, Cambridge (Drs Kolodny and Kohler); and Department of Chemistry, Wellesley College, Wellesley, Mass (Dr Kolodny and Mss Murphy and Yun).

Arch Ophthalmol. 1987;105(11):1532-1536. doi:10.1001/archopht.1987.01060110078036

• Clinical evaluation of uveal melanomas by magnetic resonance imaging (MRI) techniques depends on developing an understanding of the appearance of these tumors in magnetic resonance (MR) images. We have determined MR characteristics of uveal melanomas by proton (1H) and sodium 23 MRI of freshly enucleated human eyes at 1.5 tesla. The MR images were obtained using two-turn proton and 23Na surface coils, designed to both transmit and receive the radiofrequency signal. Proton MRI techniques included saturation recovery and spin echo; the gradient-recalled echo technique was used for 23Na MRI. Proton and 23Na MR images provide complementary information; contrast between intraocular tumors and vitreous, lens, or subretinal hemorrhage may be varied by using MR pulse sequences that emphasize tissues based on T1, T2, proton, or sodium density values. A combination of proton and 23Na MRI provides differentiation between normal ocular structures and intraocular tumors, as well as associated complications, such as retinal detachments and subretinal hemorrhages.

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