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November 1987

The Intraocular Environment and Experimental Anaerobic Bacterial Endophthalmitis

Author Affiliations

From the Department of Ophthalmology, University of Southern California, and the Estelle Doheny Eye Foundation, Los Angeles (Drs Ormerod and Smith and Mr Juarez), the Research Service and Infectious Diseases Section, Veterans Administration Wadsworth Medical Center, Los Angeles, and the Department of Medicine, UCLA (Ms Edelstein and Dr Finegold); and the Eye Research Institute of the Retina Foundation, Boston (Drs Ormerod and Schmidt).

Arch Ophthalmol. 1987;105(11):1571-1575. doi:10.1001/archopht.1987.01060110117044

• Anaerobic bacteria are prevalent in conjunctival flora but have not been adequately investigated as possible causes of endophthalmitis. The mean oxidationreduction potential (Eh) of the rabbit vitreous was found to be +25.1 mV, well within the limiting Eh value of many anaerobes. There was an oxygen pressure gradient in the vitreous ranging from 2.1 mm Hg immediately posterior to the lens to approximately 20 mm Hg adjacent to the medullary ray. Endophthalmitis was produced with pure cultures of Fusobacterium necrophorum, Propionibacterium acnes, and Peptostreptococcus magnus. Relatively small inoculates of F necrophorum caused severe, acute endophthalmitis with scleral perforation; P acnes and P magnus produced a self-limited endophthalmitis; and vitreoretinal fibrosis was a sequela of the Propionibacterium acnes infection.

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