• In a patient with neurofibromatosis and orbital optic glioma, T2-weighted axial magnetic resonance images showed a fusiform area of high signal intensity with a central linear core of lower signal intensity. Computed tomographic images did not show a corresponding variation in tumor density. Histopathologic examination of the tumor revealed dense, circumferential, perineural glial proliferation. This "arachnoidal gliomatosis" is a feature of orbital optic gliomas in neurofibromatosis and, in our magnetic resonance scans, accurately corresponded with the region of high signal intensity within the tumor.
Seiff SR, Brodsky MC, MacDonald G, Berg BO, Howes EL, Hoyt WF. Orbital Optic Glioma in Neurofibromatosis: Magnetic Resonance Diagnosis of Perineural Arachnoidal Gliomatosis. Arch Ophthalmol. 1987;105(12):1689–1692. doi:10.1001/archopht.1987.01060120087032
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