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March 1988

Toxicity of Flurbiprofen Sodium

Arch Ophthalmol. 1988;106(3):311. doi:10.1001/archopht.1988.01060130337009

To the Editor.  —Flurbiprofen sodium (0.03%) (Ocufen) is a recently approved nonsteroidal anti-inflammatory drug for the maintenance of intraoperative pupillary dilation during cataract surgery. Initial reports of its efficacy have been favorable.1,2 There have been few reports of side effects. The package insert states that the most frequent reactions are transient burning and stinging on instillation. The insert also states that there is a hypothetical possibility of intraoperative hemorrhage via interference with thrombocyte aggregation. I recently encountered a perioperative complication that may be attributed to interference with the clotting mechanism.

Report of a Case.  —An 84-year-old man was scheduled to undergo extracapsular cataract extraction in the left eye with posterior chamber lens implantation. Before surgery, the patient was taking chlorpropamide and dipyridamole. One hour and 30 minutes before surgery, one drop of 0.03% flurbiprofen sodium was instilled into the left eye. In addition, 1% tropicamide and 2.25% phenylephrine