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March 1988

Aqueous Humor Penetration of Ciprofloxacin in the Human Eye

Author Affiliations

From the Department of Medicine, Section of Infectious Diseases (Drs Skoutelis, Chrysanthopoulos, and Bassaris), and the Department of Ophthalmology (Dr Gartaganis), University of Patras (Greece) School of Medicine; and the Bayer AG, Wuppertal, West Germany (Drs Beermann and Papachristou).

Arch Ophthalmol. 1988;106(3):404-405. doi:10.1001/archopht.1988.01060130430035

• Two doses of ciprofloxacin were administered intravenously, 200 mg every 12 hours, to 25 patients undergoing cataract surgery. Plasma and aqueous humor were obtained at 1, 3, 5, 7, and 9 hours after the administration of the second dose of the drug. Peak intraocular concentrations (mean ± SD), 0.21 ±0.1 mg/L, were detected at one hour following ciprofloxacin administration. A time-dependent decrease of the penetration was observed, and by nine hours after the administration, ciprofloxacin levels were 0.05 mg/L. These results illustrate that ciprofloxacin may be an effective antimicrobial agent for prophylactic use in ophthalmologic surgery and also for the treatment of intraocular infections due to susceptible organisms.

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