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April 1988

On Prostaglandins and Ocular Fluid Dynamics

Arch Ophthalmol. 1988;106(4):449. doi:10.1001/archopht.1988.01060130491011

To the Editor.  —Literary license can at times be excessive, especially when certain basic facts are overlooked, and I found this to be particularly true in a recent editorial.1The author refers to a "phenomenon that can be most annoying to ocular physiologists" relative to mediators of ocular irritative responses; I assume that phenomenon refers to the role of these mediators. The use of crude tissue preparations to help in the beginning stages of the elucidation of physiologic responses is a well-known physiologic approach to many types of tissues and many types of responses. However, the causal relationships between eicosanoids and ocular fluid dynamics certainly involve the pioneering efforts of Ambache and colleagues2,3 in their studies with "Irin." These efforts, to which the editorial refers, must be credited with triggering much of our current knowledge in this field, and I hope Dr Bito agrees. The editorial also states