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April 1988

Sodium Hyaluronate and Polyvinyl Alcohol Artificial Tear Preparations: A Comparison in Patients With Keratoconjunctivitis Sicca

Author Affiliations

From the Departments of Ophthalmology, St Paul-Ramsey Medical Center, St Paul and the University of Minnesota, Minneapolis (Dr Nelson); and Columbia University, New York (Dr Farris).

Arch Ophthalmol. 1988;106(4):484-487. doi:10.1001/archopht.1988.01060130530029

• An unpreserved artificial tear substitute containing 0.1% sodium hyaluronate was compared with a preparation containing 1.4% polyvinyl alcohol and 0.5% chlorobutanol in a controlled, double-masked, randomized study in patients with moderately severe keratoconjunctivitis sicca. Patients were evaluated initially, at 1, 4, and 8 weeks. The dry-eye status was evaluated by means of tear-film osmolality, tear breakup time, rose bengal staining, Schirmer's test (without anesthesia), and ocular surface-impression cytology. In general, neither preparation was found to be superior to the other. In both study groups, the mean tear-film osmolality and rose bengal staining score improved over the eight-week study, but the degree of squamous metaplasia of the bulbar conjunctival surface, as shown by impression cytology, did not change significantly.

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