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June 1988

Goblet Cell Density in Thermal and Chemical Injuries-Reply

Author Affiliations

Osaka, Japan

Arch Ophthalmol. 1988;106(6):723. doi:10.1001/archopht.1988.01060130792015

In Reply.  —Dr Brent makes some interesting suggestions; however, his hypothesis regarding "apparent" as opposed to "real" goblet cell density requires at least an increase in the remaining cell density at the scarred ocular surface, which is not the case in our series; we observed no statistical difference in conjunctival epithelial density between injured and normal eyes. As well, our preliminary results indicated that the adhesive power of epithelia, including goblet cells, to the filtering paper was less in scarred than in normal conjunctiva. Our data regarding goblet cell density were unaffected by this variability, however, due to our method of calculation. Supposing goblet cell density were to be reflected in conjunctival differentiation,1 a marked decrease in goblet cell density during the acute stage of chemical injury2 may be due to insufficient conjunctival differentiation, not to simple inflammation or direct goblet cell damage. Further investigations should be directed

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