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Article
July 1988

Cytomegalovirus Transmission and Corneal Transplantation

Author Affiliations

Collaborative Corneal Transplantation Studies Baltimore

Arch Ophthalmol. 1988;106(7):877. doi:10.1001/archopht.1988.01060140019003
Abstract

To the Editor.  —Transmission of cytomegalovirus (CMV) from infected donors to recipients is a serious concern in the transplantation of bone marrow, kidneys, and other vascularized organs. Because the immune systems of these recipients are severely compromised by cytotoxic drug and systemic steroid therapies, primary or secondary infection with CMV may cause a variety of clinical diseases, such as hepatitis, pneumonitis, and retinitis. Usually, serologic testing of corneal donors and recipients for antibodies to CMV is not performed. However, when presented with a positive serologic test result from a multiple organ donor, the corneal surgeon may feel uncomfortable in accepting a cornea for transplantation into a patient whose serologic CMV status is unknown. In fact, we know of at least two instances in which tissue was refused by a corneal surgeon solely on the basis of a positive CMV test result from the donor. Since seropositivity in the general population

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