In the June 1988 issue of the Archives, Wright and colleagues1 described a well-conceived clinical trial designed to determine if capsulotomy affects the incidence of angiographic or visually significant cystoid macular edema (CME). The study protocol includes (1) a well-defined patient population consisting of 162 patients older than 60 years of age undergoing planned extracapsular cataract surgery or phacoemulsification with placement of a posterior chamber lens; (2) a prospective clinical trial in which 141 of the 162 cases were randomized to a surgical capsulotomy or an intact posterior capsule; (3) excellent follow-up, ie, an impressive 96% of patients underwent fluorescein angiography very close to six weeks postoperatively and in a subgroup of patients, 96% of randomized eyes underwent angiography six months following surgery; and (4) a careful masked evaluation of the angiograms.
Nineteen percent of the eyes showed angiographic CME six weeks following surgery. In 2.5% of eyes,
Jampol LM. Cystoid Macular Edema Following Cataract Surgery. Arch Ophthalmol. 1988;106(7):894–895. doi:10.1001/archopht.1988.01060140040018
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