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July 1988

Positive Correlation of Corneal Thickness and Endothelial Cell Loss: Serial Measurements After Cataract Surgery

Author Affiliations

From The Eye Hospital, Oxford, England (Dr Cheng); Moorfields Eye Hospital, London (Dr Bates); and the Department of Community Medicine and General Practice, Oxford (England) University (Dr McPherson).

Arch Ophthalmol. 1988;106(7):920-922. doi:10.1001/archopht.1988.01060140066026

• A significant linear correlation was found between increase in corneal thickness (ACT) in the immediate postoperative period and percentage of cell loss one and six months after surgery in a prospective study on cataract surgery. Eyes were grouped according to ACT, and the groups were compared according to the percentage of cell loss. Eyes with ACT of 0.1 mm or more at five days lost significantly more cells at one and six months than eyes with ACT of less than 0.025 mm. Eyes were then regrouped according to the percentage of cell loss. Those with cell loss of 30% or more were found to have significantly greater ACT at 48 hours and five days than eyes with cell loss of less than 30%. The derived probability of cell loss of 30% or more increases the greater the value of ACT. For ACT of 100 μm or more at five days, the probability of high cell loss is 30%; this is nearly three times the likelihood that high cell loss had occurred when ACT is less than 100 μm. Our results suggest that ACT could be a useful clinical indicator of endothelial cell loss.

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