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July 1988

Hemoglobin Spherulosis in the Vitreous Cavity

Author Affiliations

From the Division of Ophthalmology (Drs Grossniklaus and Frank) and Department of Pathology (Drs Grossniklaus, Farhi, and Jacobs), University Hospitals of Cleveland, Case Western Reserve University, Cleveland; and the Eye Pathology Laboratory, The Johns Hopkins Hospital, Baltimore (Dr Green).

Arch Ophthalmol. 1988;106(7):961-962. doi:10.1001/archopht.1988.01060140107035

• A 50-year-old woman was evaluated for a subretinal hemorrhage that extended into the vitreous of the right eye. Examination showed multiple refractile brown spherules in the vitreous. A vitrectomy was performed, and pathologic examination of the spherules showed them to be composed of free hemoglobin. Free-hemoglobin spherulosis in the vitreous, like cholesterosis bulbi, is a manifestation of vitreous hemorrhage.

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