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September 1988

Multiple Evanescent White Dot Syndrome

Arch Ophthalmol. 1988;106(9):1162-1163. doi:10.1001/archopht.1988.01060140322006

To the Editor.  —I found the article by Fletcher et al1 fascinating. I agree, on reading the clinical course and examination findings, that the cause is likely to be retinal. I question, however, whether results of the fundus examination were normal in the two cases for which photographs were published. Both show focal areas of retinal pigment epithelial hyperfluorescence. Additionally, the fluorescein angiogram of patient 2 may have some leakage at least at the 12- and 4-o'clock optic disc locations (possibly more diffuse in the later angiogram). Both the fundus photograph and fluorescein angiogram of patient 7 appear blurred, consistent with mild disc edema (only a late-stage angiogram could show certain results). I therefore think the findings of mild diffuse pigment epithelial affliction, electroretinographic abnormalities, probable mild disc edema, and corresponding enlarged visual-field blind spot are consistent with the multiple evanescent white dot syndrome (MEWDS). This presentation and

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