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September 1988

Resolution of Cytomegalovirus Retinitis With Zidovudine Therapy

Arch Ophthalmol. 1988;106(9):1168-1169. doi:10.1001/archopht.1988.01060140328016

To the Editor.  —Cytomegalovirus (CMV) retinitis is a substantial cause of morbidity in patients with acquired immunodeficiency syndrome (AIDS). Recently, a beneficial effect of treatment with ganciclovir, an acyclovir derivative with activity against CMV in vitro, has been reported.1Zidovudine (formerly known as azidothymidine [AZT]) is a dideoxythymidine compound with antiviral activity against human immunodeficiency virus (HIV). This study documents regression of CMV retinitis in a patient with AIDS who elected to receive zidovudine therapy without ganciclovir treatment.

Report of a Case.  —A 26-year-old homosexual man was diagnosed as having AIDS in July 1986, when he developed Pneumocystis carinii pneumonia. In addition, CMV and Mycobacterium avium intracellulare were recovered from a bronchoalveolar lavage specimen at this time. He recovered after three weeks of trimethoprim and sulfamethoxazole therapy. On Sept 23, 1986, he was examined for a complaint of blurred vision in his left eye. Visual acuity was 20/20

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