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December 1988

Retinal Thinning and Regression of Neovascularization-Reply

Arch Ophthalmol. 1988;106(12):1647. doi:10.1001/archopht.1988.01060140818004

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In Reply.  —In my article I reviewed a number of recently discovered cell-derived factors that have been found to modulate neovascularization. I also cited extensive studies demonstrating that cells of the retina and retinal pigment epithelium can release many of these modulators of neovascularization as a reaction to a number of stimuli. These facts prompted the suggestion that "Laser treatment may have its effect via subsequent alterations in the production of these cell-derived factors that occur during the healing process and within the resulting scar." In other words, the reactive changes of the retinal pigment epithelium and retinal cells during subsequent scar formation may induce the release of neovascular inhibitors by these cells.Dr Campochiaro now cites a single case report in which regression of NVD was associated with the development of optic atrophy. He concludes from this single case that an alteration in the synthesis and release of neovascular

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