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March 1989

Dextromethorphan Protects Retina Against Ischemic Injury In Vivo

Arch Ophthalmol. 1989;107(3):409-411. doi:10.1001/archopht.1989.01070010419037

• Retinal ischemia was induced in rabbits by increasing intraocular pressure above systolic blood pressure for 60 or 75 minutes, and retinal function was monitored by electroretinography. Pretreatment with intravenous dextromethorphan, a nonprescription antitussive and selective antagonist of N-methyl-d-aspartate receptors, enhanced greatly the post-ischemic recovery of b-wave amplitude. Dextromethorphan may prove to be useful clinically in the management of retinal ischemic disease.