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April 1989

The Association of Posterior Capsular Lens Opacities With Bilateral Acoustic Neuromas in Patients With Neurofibromatosis Type 2

Author Affiliations

From the Clinical Branch (Drs Kaiser-Kupfer, Datiles, and Edwards and Ms McCain) and Biometry and Epidemiology Program (Dr Freidlin), National Eye Institute; Uniformed Services University of Health Sciences (Dr Sherman); Clinical Epidemiology Branch (Dr Parry), National Cancer Institute; and the Neuroepidemiology Branch (Dr Eldridge), National Institute of Neurologic and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md.

Arch Ophthalmol. 1989;107(4):541-544. doi:10.1001/archopht.1989.01070010555030

• This study of 47 patients from 11 families with neurofibromatosis type 2 (NF 2) confirms our previously reported association between posterior capsular cataract and NF 2. A highly significant statistical association was found between the presence of posterior capsular lens opacities and the presence of NF 2 as determined by magnetic resonance imaging or pathologic diagnosis. This association was not present for other types of lens opacities that could be the result of age-related or nonspecific changes. When considering the diagnosis of NF 2, this finding now makes it essential to use a careful dilated biomicroscopic examination of the lens to evaluate known, suspected, or at-risk individuals for this potentially early associated manifestation.

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