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May 1989

Sharing Tissue Typing Information From the Collaborative Corneal Transplantation Studies

Author Affiliations

Study Cochairmen
Baltimore, Md

Arch Ophthalmol. 1989;107(5):633. doi:10.1001/archopht.1989.01070010651004

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To the Editor.  —The principal investigators of the Collaborative Corneal Transplantation Studies (CCTS), a National Eye Institute-sponsored multicentered clinical trial of histocompatibility matching in high-risk keratoplasty, have received several inquires regarding our position on recommendations for tissue matching and sharing of typed tissue.We believe that the available data do not, at this time, allow us to determine whether histocompatibility matching improves the prognosis for penetrating keratoplasty in high-risk recipients. Available data do not allow us to determine whether histocompatibility matching, if effective, should be based on HLA-A matches, HLA-B matches, HLA-DR matches, or ABO matches. It is the purpose of the CCTS to address these and other questions.The CCTS is a masked, prospective, randomized clinical trial. Consequently, none of the investigators is aware of the degree of tissue match that any of his patients receive. Data are reviewed biannually by the CCTS Data and Safety Monitoring Committee. At

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