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June 1989

Danazol, Premenstrual Tension, and Uveitis

Author Affiliations

Newcastle-Upon-Tyne, United Kingdom

Arch Ophthalmol. 1989;107(6):796. doi:10.1001/archopht.1989.01070010818013

To the Editor.  —It is known that the menstrual cycle may be associated with eye symptoms. Danazol is a weakly androgenic 2,3-isoxazol derivative of 17 x-ethyl testosterone and is used to treat various disorders, including premenstrual tension. In this report, the role of danazol in the treatment of a patient suffering from premenstrual tension and acute iridocyclitis secondary to ankylosing spondylitis is reported.

Report of a Case.  —A healthy 30-year-old woman first presented with severe acute iridocyclitis, secondary glaucoma, and sterile hypopyon in the right eye, which responded favorably to treatment with topical steroids and mydriatic agents. She was also found to be HLA-B27 positive and was suffering from ankylosing spondylitis.Over the following three years, she suffered nine acute attacks of iridocyclitis in the same eye, four of which required systemically administered steroids in addition to topical treatment to induce remission. Rarely was she not receiving treatment, and over

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