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July 1989

Intraocular Neovascularization and Retinal Energy Metabolism-Reply

Author Affiliations

Charlottesville, Va

Arch Ophthalmol. 1989;107(7):953-954. doi:10.1001/archopht.1989.01070020015006

In Reply.  —I am grateful for the comments of Dr Wilson, as they offer me an opportunity to clarify, I hope, some misinterpretations of the discussion concerning involution of retinal neovascularization that appeared in the December 1988 issue of the Archives. In that discussion, I stated that optic atrophy (and possibly some other conditions, such as high myopia and extensive chorioretinal scarring), like scatter photocoagulation,1 might result in improved oxygenation of the remaining viable retina, and this may play a role in involution of neovascularization. I did not discuss the mechanism by which improved oxygenation occurs. In fact, I specifically avoided it because it may vary somewhat among the various conditions I mentioned. I agree with Dr Wilson that decreased oxygen utilization is likely to be an important cause of improved oxygenation, particularly in the setting of optic atrophy. I did not suggest that optic atrophy causes an increase

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