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July 1989

Identification and Significance of Multinucleate Tumor Cells in Retinoblastoma

Author Affiliations

From the David G. Cogan Eye Pathology Laboratory, Harvard Medical School and Massachusetts Eye and Ear Infirmary (Ms Howard and Drs Dryja and Albert), and the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary (Dr Walton), Boston, Mass.

Arch Ophthalmol. 1989;107(7):1025-1030. doi:10.1001/archopht.1989.01070020087037

• Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.

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