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September 1989

Posterior Vitreous Fluorophotometry: II. Comparison of Diabetic Patients and Controls With the Use of a New Analysis Procedure

Author Affiliations

From the Clinical Branch, National Eye Institute (Dr Roy), and the Biomedical Engineering and Instrumentation Branch, Division of Research Services (Drs Bungay and Bonner), National Institutes of Health, Bethesda, Md.

Arch Ophthalmol. 1989;107(9):1328-1333. doi:10.1001/archopht.1989.01070020398043

• We used a new computerized procedure to analyze posterior vitreous fluorophometry scans, obtained with a commercial fluorophotometer (Fluorotron Master Coherent, Palo Alto, Calif), in insulin-dependent diabetic patients and controls. Diabetic patients with minimal retinopathy had significantly higher effective fluorescein vitreous diffusivity and 30-minute 3-mm vitreous fluorescence values than either controls or diabetic patients with no retinopathy. However, there was no significant difference between the groups for the apparent permeability of the blood-retinal barrier to fluorescein. These results suggest the possibility that the higher 3-mm fluorescence levels found in the diabetic patients with minimal retinopathy may result in part from enhanced movement of fluorescein through the vitreous.

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