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September 1989

Immunocytochemical Localization of Ornithine Aminotransferase in Human Ocular Tissues

Author Affiliations

From the Departments of Ophthalmology (Drs Mito, Shiono, Ishiguro, Tamai, and Mizuno) and Pediatrics (Dr Ohura), Tohoku University School of Medicine, Sendai, Japan.

Arch Ophthalmol. 1989;107(9):1372-1374. doi:10.1001/archopht.1989.01070020442051

• Gyrate atrophy of the choroid and retina is a rare inherited form of chorioretinal degeneration caused by a deficiency of ornithine aminotransferase. We localized the enzyme in human ocular tissues using immunocytochemical procedures. Immunoreactivity was observed in the nonpigmented epithelium of the ciliary body and lens epithelium. In the retina, ganglion cells and some amacrine cells were immunoreactive. Pigmented granules made it difficult to identify immunoreactive products in the iris, pigmented epithelium of the ciliary body, choroid, and retinal pigment epithelium. Our findings suggested that ornithine aminotransferase plays an important role in ornithine metabolism in these oculartissues.