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October 1989

Transforming Growth Factor Beta Does Not Work Without Angiogenesis In Vivo

Arch Ophthalmol. 1989;107(10):1420-1421. doi:10.1001/archopht.1989.01070020494010

To the Editor.  —I appreciate the observation of Smiddy et al1 that transforming growth factor beta may be used for inducing a chorioretinal adhesion in the treatment of retinal tears. I must disagree, however, with their statement that no neovascularization was observed in any specimen.It is accepted generally that angiogenesis is an inherent part of repair. Since consensus is not a guarantor of truth, I would like to draw the readers' attention to the fact that even Smiddy et al present neovascularization quite clearly. In Fig 5 of their article, black autoradiographic grains delineate discernible vascular lumina several times. Also, the largest solid black grains exceed the dimensions of individual interstitial cells and represent the hyperplastic capillary sprouts that are observed in repair.2So the original observation of Roberts et al3 that transforming growth factor beta induces both angiogenesis and fibrosis is confirmed.

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