Whether crystals typical of cystinosis appear within the corneal stroma of a donor button transplanted into the eye of a patient with nephropathic cystinosis has become controversial.1-3 We described a patient who had bilateral penetrating keratoplasties and nephropathic cystinosis, and who—when examined some 6 weeks after transplant—exhibited crystals typical of cystinosis within his donor button.1 The same patient examined elsewhere 10 months after transplantation was described as having a clear corneal graft.2 We had the opportunity to examine another patient with nephropathic cystinosis who also underwent penetrating keratoplasty and again to document the recurrence of corneal crystal deposition within a donor button.
Report of a Case.
—A 19-year-old woman with juvenile nephropathic cystinosis underwent two renal allografts. Her systemic medications included prednisone and azathioprine. Ophthalmic evaluation documented characteristic crystals of cystinosis within the conjunctiva and cornea. She presented with presumed pupillary block glaucoma of the left eye.
Katz B, Melles RB, Schneider JA. Crystal Deposition Following Keratoplasty in Nephropathic Cystinosis. Arch Ophthalmol. 1989;107(12):1727–1728. doi:10.1001/archopht.1989.01070020809012
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