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February 1990

Five-Year Follow-up of Helium Ion Therapy for Uveal Melanoma

Author Affiliations

From the Ocular Oncology Unit (Dr Char and Mr Kroll), the Departments of Ophthalmology (Drs Char, Irvine, and Stone) and Radiation Oncology (Drs Char and Quivey), and the Francis I. Proctor Foundation (Dr Char), the University of California, San Francisco; and the Lawrence Berkeley Laboratory, the University of California, Berkeley (Dr Castro).

Arch Ophthalmol. 1990;108(2):209-214. doi:10.1001/archopht.1990.01070040061031

• One hundred sixty-four patients with uveal melanoma were treated with helium ion irradiation prior to May 1984, and the data were analyzed in June 1989. Most uveal melanomas were large, with a mean tumor thickness of 6.5 mm; approximately 60% of the patients had tumors that extended anterior to the equator. A complete follow-up was obtained for all patients. One hundred twelve patients were alive at the time of this report; 18% of the patients developed clinical and laboratory evidence of metastases and eventually died of widespread tumor. Eighty-four percent of eyes were retained. Data were analyzed with a number of parametric and nonparametric techniques. Larger tumors and those located in close proximity to the optic nerve and fovea had a higher incidence of most complications, especially visual loss.

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