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March 1990

Retinal Findings in the Fat Overload Syndrome

Author Affiliations

USA; USA; USA; Aurora, Colo

Arch Ophthalmol. 1990;108(3):329. doi:10.1001/archopht.1990.01070050027012

Parenteral hyperalimentation using lipid is considered an effective and relatively safe method of delivering essential nutrients to patients unable to tolerate enteral feedings. Although the fat overload syndrome is a well-recognized complication of intravenous lipid therapy, its ocular manifestations have not been previously described, to our knowledge.1-3

Report of a Case.  —A 38-year-old Hispanic man was admitted to a community hospital with fever, cough, wheezing, and a lung infiltrate. He was initially treated with bronchodilators, antibiotics, and supplemental oxygen. On the second hospital day parenteral hyperalimentation, which included a 20% fat emulsion infusion (Liposyn II, Abbott Laboratories, Chicago, Ill) was initiated. During the next 5 days the patient was iatrogenically lipid overloaded, receiving 11L of 20% Liposyn II (6.2 g of fat per kilogram of body weight per day). The maximum recommended dosage of Liposyn II is 3.0 g of fat per kilogram of body weight per day. During