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March 1990

Conjunctival Concretions: Polarized Microscopic, Histopathologic, and Ultrastructural Studies

Author Affiliations

From the Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan.

Arch Ophthalmol. 1990;108(3):405-407. doi:10.1001/archopht.1990.01070050103042

• To elucidate the pathophysiologic features of conjunctival concretions, we performed polarized microscopic examinations, immunocytochemical studies, histochemical stains, and electron microscopic studies of concretions obtained from five patients with chronic conjunctivitis. Electron-dense secretory granules, ranging from 0.2 to 0.5 μm in diameter and stained positively for periodic acid—Schiff and mucicarmine, were found in the superficial lining epithelial cells of the pseudogland of Henle. In view of the granular and membranous figures reflecting degenerating epithelial cells and secretory granules in the concretions, we argue that the concretions are mostly composed of the mucinous secretion of the transformed conjunctival glands admixed with the degenerative products of the epithelial cells.