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March 1990

Glaucoma Filtration Surgery in Monkeys Using 5-Fluorouridine in Polyanhydride Disks

Author Affiliations

From the Glaucoma Service, The Wilmer Ophthalmological Institute (Drs Jampel and Quigley and Mr Dunkelburger) and the Department of Biomedical Engineering (Dr Leong), The Johns Hopkins University School of Medicine, Baltimore, Md.

Arch Ophthalmol. 1990;108(3):430-435. doi:10.1001/archopht.1990.01070050128046

• We performed filtration surgery in glaucomatous monkeys to determine if bioerodible polyanhydride disks that contained 5-fluorouridine (5-FUR) prolonged the success of the operation. First, in vitro studies demonstrated that 5-fluorouridine was released from the disks for at least 16 days in a bioactive form that inhibited fibroblast proliferation. Next, a preliminary series of six eyes suggested that using disks that contained 5-fluorouridine extended the intraocular pressure—lowering effect of filtration surgery. This finding was confirmed in eight additional eyes of four animals in which one eye received a disk with 5-fluorouridine and the other received a disk without the drug. The duration of success of the operation was significantly longer in the eyes that received polyanhydride with 5-fluorouridine (mean ± SD, 26.0 ± 9.2 days) than in the controls (8.5 ± 4.0 days). The histologic findings of the experimental eyes correlated with their prolonged clinical success.