[Skip to Navigation]
April 1990

Protracted Uveitis as the Initial Manifestation of Wegener's Granulomatosis

Author Affiliations

Tampa, Fla

Arch Ophthalmol. 1990;108(4):478-479. doi:10.1001/archopht.1990.01070060024008

To the Editor.  —Wegener's granulomatosis (WG) is a systemic inflammatory disease characterized by the elinicopathologic triad of necrotizing granulomatous vasculitis affecting the upper and lower respiratory tract that is often associated with glomerulonephritis. Localized forms of WG that are limited primarily to the upper or lower respiratory tract are also known to exist. Organs other than the respiratory tract and kidneys, such as the skin and eyes, may be involved by an associated systemic disseminated vasculitis.1 Although the lungs and kidneys are the classic target organs, the vasculitis may affect other organs for prolonged intervals before the more characteristic manifestations become evident. This protracted phase of the disease has been referred to as pathergic granulomatosis.2 In this case report we describe a patient who had a 4-year history of chronic uveitis before an open lung biopsy established the diagnosis of WG.

Report of a Case.  —A 50-year-old white

Add or change institution