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April 1990

In Vivo Angiogenic Activity of Interleukins

Author Affiliations

From the Pediatric and Immuno-Ophthalmology Unit and the Laboratory of Ocular Angiogenesis, Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.

Arch Ophthalmol. 1990;108(4):573-576. doi:10.1001/archopht.1990.01070060121061

• Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus. A constant and reproducible neovascular stimulus was observed with 5 ng per implant of recombinant human interleukin 1 alpha or 100 ng per implant of recombinant human interleukin 1 beta. At these concentrations, neither tumor necrosis factor nor interleukin 2 induced any neovascular stimulus. These data are interpreted as an indication for the possible role of interleukin 1 in angiogenesis of ocular (and other) tissues. As interleukin 1 is produced by various cells, it is hypothesized that this molecule may be the "unitarian angiogenic factor."

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