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May 1990

Basic and Clinical Aspects of Malignant Melanoma

Author Affiliations

Boston, Mass

Arch Ophthalmol. 1990;108(5):655. doi:10.1001/archopht.1990.01070070041027

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This book is a volume of the Cancer Treatment and Research series whose goal, according to the series editor, is to provide authoritative articles on major oncology problems.

The book is presented in three sections. The first is devoted to the basic biology of melanoma and includes three reviews: the role of oncogenes in the pathogenesis of melanoma, the modulation of metastatic activity of melanoma by the matrix molecules of laminin and fibronectin and structure, and function and biosynthesis of ganglioside antigens associated with neuroectodermal tumors. All three articles are excellent state-of-the-art reviews of these topics and are followed by an extensive bibliography.

The second section is titled "Natural History" and includes a thorough and detailed review on the epidemiology of ocular melanoma, which ophthalmologists particularly will enjoy. Other articles in this section discuss prognostic factors, endocrine influences on the natural history, biopsychosocial aspects of cutaneous malignant melanoma, and central

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