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May 1990

HLA-B7 and HLA-DR2 Antigens and Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Author Affiliations

From the Departments of Ophthalmology (Drs Wolf and Folk, and Ms Panknen) and Internal Medicine and Pathology (Dr Goeken), University of Iowa, Iowa City.

Arch Ophthalmol. 1990;108(5):698-700. doi:10.1001/archopht.1990.01070070084040

• Acute posterior multifocal placoid pigment epitheliopathy is a chorioretinal inflammatory disease occurring in young, healthy adults. Its cause is unknown, although it frequently follows a flulike illness. We reexamined 30 patients with documented acute posterior multifocal placoid pigment epitheliopathy to determine their HLA class I antigen (A and B) and class II antigen (DR and DQ) distribution. The HLA class I antigen B7 was found in 12 patients (40.0%) compared with 63 controls (16.6%) (relative risk, 3.38). The class II antigen DR2 was present in 17 patients (56.7%) compared with 107 controls (28.2%) (relative risk, 3.34). The specific role of HLA antigens in uveitis is unknown, but the finding of an increased prevalence of HLA-B7 and HLA-DR2 antigens in patients with acute posterior multifocal placoid pigment epitheliopathy suggests an immunogenetic predisposition to acquiring this disease.

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