To the Editor.
—It is distressing that the Archives has published a report that appears to suffer so glaringly from a lack of objectivity.1The study by Tripathi and Tripathi demonstrates that continuous bathing of cultured in vitro human corneal epithelial cells at low levels of hydrogen peroxide during a several-hour period (30 ppm for 4 to 5 hours) results in severe cell damage and cell death and that higher concentrations have the same effect in a shorter time.Since the levels of hydrogen peroxide studied (30 to 100 ppm) approximate those levels that may remain following soft lens disinfection, by implication, the authors attempt to indict such systems.The inclusion of the disclaimer "our experimental conditions in vitro may not be equated directly with the situation in vivo," in the next to last paragraph of a 3½-page article hardly seems adequate to offset the clear intent of the
Nicolson PC. Hydrogen Peroxide in Lens Care: Unfounded Indictments. Arch Ophthalmol. 1990;108(7):913. doi:10.1001/archopht.1990.01070090015002
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