—We have no proprietary interest in any contact lens disinfection or solution systems, and our article did not criticize or name any product on the market. It appears from Dr Nicolson's letter, however, that commercial interest in contact lens disinfection systems which use hydrogen peroxide may have influenced his objectivity in reading and interpreting the content of our article.Our study demonstrated the response of primary cultures of human corneal epithelial cells to the administration of a single dose of hydrogen peroxide at various concentrations, and not to "continuous bathing" as stated by Dr Nicolson. It must be realized that, in vitro, the hydrogen peroxide would be subjected to cell detoxification systems comparable with those present in vivo, and that the serum contained in the culture medium also quenches the activity of the peroxide.We did state in the third paragraph of the discussion that trace amounts of
Tripathi BJ, Tripathi RC. Hydrogen Peroxide in Lens Care: Unfounded Indictments-Reply. Arch Ophthalmol. 1990;108(7):913–914. doi:10.1001/archopht.1990.01070090015003
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