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July 1990

Coryneform Endophthalmitis: Two Case Reports

Author Affiliations

From the Department of Ophthalmology (Drs McManaway and Weinberg) and the Clinical Microbiology Laboratory (Dr Coudron), Medical College of Virginia, Richmond. Dr McManaway is now with the Department of Ophthalmology at the Milton S. Hershey Medical Center, Hershey, Pa.

Arch Ophthalmol. 1990;108(7):942-944. doi:10.1001/archopht.1990.01070090044036

• Recent clinical studies have emphasized the importance of diphtheroids, previously regarded as nonpathogenic bacteria or contaminants, as causes of ocular disease. We encountered two patients with endophthalmitis following cataract extraction and anterior chamber intraocular lens implantation. Both patients had previously been treated with subconjunctival and/or oral corticosteroids for presumed sterile endophthalmitis. Vitreous cultures in each case yielded pure growth of a diphtheroid that was subsequently identified as coryneform group A-4. The clinical response to standard intraocular therapy with gentamicin and cefazolin was delayed, although both patients eventually had restoration of functional vision. A comparison of the antibiotic minimum inhibitory and minimum bactericidal concentrations of the isolates may help to explain the delayed response to therapy seen in these two patients.

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