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August 1990

Experimental Use of Semiconductor Diode Laser in Contact Transscleral Cyclophotocoagulation in Rabbits

Author Affiliations

From the Morse Laser Center, Howe Laboratory of Ophthalmology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.

Arch Ophthalmol. 1990;108(8):1152-1157. doi:10.1001/archopht.1990.01070100108044

• Acute and long-term effects of contact transscleral semiconductor diode laser cyclophotocoagulation were studied in rabbits. Immediately following cyclophotocoagulation, light microscopy revealed coagulation necrosis of the ciliary pigmented and nonpigmented epithelia and stroma; destruction increased in relation to power. There was architectural disruption with higher energy levels. The findings with diode and continuous-wave contact neodymium-YAG lasers were similar. In rabbits treated and followed up for 6 weeks there was a decrease in intraocular pressure during the observation period (P <.05, paired Student's t test). The gross and light microscopic examination revealed focal atrophy and fibrosis of the ciliary processes, with pigment-laden macrophages on the ciliary processes and in the outflow pathways. Higher energy levels caused lens capsule damage and vitritis. The diode laser produced ciliary destruction similar to the continuous-wave contact neodymium-YAG laser in rabbits, with significant intraocular pressure lowering during the 6-week follow-up.

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