To the Editor.
—The editorial committee of the Cryopathy for Retinopathy of Prematurity (ROP) Cooperative Group1 has expressed opinions and advice that are in conflict with the findings of their study. Also, the results of treatment are significantly disparate from those in three other studies. That difference requires explanation, and the direction being given to ophthalmology must be challenged.The study shows that treatment of zone I disease does not produce a significant benefit (P≃0.4; x2 [Yates corrected]). The trend may be there but the proof is not, yet they recommended treatment of both eyes.The study shows a highly significant benefit to the treated eyes with bilateral zone II threshold disease (P <.0001; x2) and they do not recommend treatment of both eyes! They cite a proposal for the determination of treating both eyes,2 which is flawed3,4 and so complex that it is
Hindle NW. Cryotherapy for Retinopathy of Prematurity: None, One, or Both Eyes. Arch Ophthalmol. 1990;108(10):1375. doi:10.1001/archopht.1990.01070120021003
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