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October 1990

Cryotherapy for Retinopathy of Prematurity: None, One, or Both Eyes-Reply

Author Affiliations

Portland, Ore

Arch Ophthalmol. 1990;108(10):1375-1376. doi:10.1001/archopht.1990.01070120021004

In Reply.  —The misconception that our report is contradictory deserves a reply, and we welcome the opportunity to further discuss and clarify the intent, design, results, and recommendations of the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP).This study was designed to test the results of cryotherapy for a defined threshold severity of ROP occurring posterior to zone 3 of the retina. It would have been presumptuous to test for the optimal stage (or other variables) at which to apply a treatment for which efficacy had not previously been adequately studied.The subgroup of zone 1 cases, when separately analyzed, contains an insufficient sample size to demonstrate a significant benefit in that particular subgroup, even if it exists. However, as our report stated, cryotherapy clearly benefits threshold stage 3+ ROP in zone 2, and the data are consistent with the finding that it also benefits some cases of

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