—Dr Abramson seems concerned that some cases of retinoblastoma may be missed by the SEER program due to referrals to major treatment centers in New York and Philadelphia. Indeed, disease incidence estimates require complete ascertainment of cases among defined populations at risk. The residents in each registry constitute the populations at risk in the SEER database. Because of the geographic location of several of the registries, it seems unlikely that many children with retinoblastoma would be referred out of these registries. Furthermore, the homogeneity of incidence rates across all registries suggests that only a few cases of retinoblastoma occurring in the SEER areas may not be recorded in the registries. Therefore, we believe that there is nearly complete ascertainment of the number of retinoblastoma cases in these populations, and one may thus estimate incidence.In addition to incidence estimation, a population-based data collection system such as SEER may
Tamboli A, Podgor MJ, Horm JW. Retinoblastoma Incidence in the United States-Reply. Arch Ophthalmol. 1990;108(11):1514. doi:10.1001/archopht.1990.01070130016002
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