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November 1990

Leiomyosarcoma Metastatic to the Orbit

Author Affiliations

Boston, Mass

Arch Ophthalmol. 1990;108(11):1525-1526. doi:10.1001/archopht.1990.01070130027014

Leiomyosarcomas, malignant smoothmuscle tumors, are rare in the orbit. Ten cases of primary leiomyosarcoma have been reported in the literature.1 Of these, three appeared after irradiation for retinoblastoma. We believe this to be the first report of a leiomyosarcoma metastatic to the orbit.

Report of a Case.  —A 71-year-old man with metastatic leiomyosarcoma presented with a left orbital mass. The patient first manifested leiomyosarcoma 3 years earlier, presenting with scalp and abdominal skin lesions. One year later, he presented with a popliteal mass. Subsequent computed tomography of the chest revealed metastatic pulmonary disease. Despite five courses of doxorubicin hydrochloride, ifosfamide, and dacarbazine therapy, he had numerous recurrences of cutaneous lesions. He now presented with a firm mass beneath his upper left eyelid that had developed gradually over 5 months, causing no visual impairment. On examination, extraocular movements were full, and there was no inflammation. Visual acuity was 20/25 OU,

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