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December 1990

Ocular Penetration of Thiabendazole

Author Affiliations

Baltimore, Md; Rahway, NJ

Arch Ophthalmol. 1990;108(12):1675. doi:10.1001/archopht.1990.01070140029015

Ocular Toxocara canis infection may cause decreased vision owing to direct retinal injury by the Toxocara organism or by secondary effects related to inflammation and scarring. Several treatment modalities for ocular toxocariasis have been advocated, including systemic antiparasitic medications, photocoagulation, and vitreous surgery. Although the T canis larva is sensitive to thiabendazole (Mintezol), as used in the treatment of visceral larva migrans, it is not known whether this drug crosses the blood-ocular barrier.1

Report of a Case.  —A 7-year-old boy presented with painless loss of vision in the right eye, noted during routine visual screening. Visual acuity was 20/400 OD, 20/20 OS. Ophthalmic examination of the left eye showed it to be normal. Slit-lamp examination of the right eye revealed an uninflamed anterior segment and 1+ anterior vitreous cell. Funduscopic examination showed a large granuloma at the ora ser rata from the 6- to 9-o'clock meridian. Several vitreous snowballs

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