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January 1991

Aspergillus terreus Endophthalmitis in a Patient With Chronic Lymphocytic Leukemia

Author Affiliations

From the Department of Ophthalmology (Drs Kalina and Campbell) and the Division of Pathology (Dr Campbell), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Ophthalmol. 1991;109(1):102-103. doi:10.1001/archopht.1991.01080010104040

• A 65-year-old woman with a 7-year history of chronic lymphocytic leukemia presented with acute visual loss, pain, and redness in her right eye. Results of stains and cultures of anterior chamber fluid were negative. Neurologic problems, bronchopulmonary pneumonia, recurrent skin lesions, and a low-grade fever developed. Progressive respiratory distress ensued, and the patient died 1 month after presentation. Cultures from antemortem sputum and skin samples were positive for Aspergillus terreus. Postmortem histologic results showed extensive A terreus invasion of the posterior vitreous, retina, choroid, and anterior optic nerve. This organism was also found in histologic sections from the right adrenal gland, left kidney, thyroid, urinary bladder, right lung, skin, esophagus, sputum, vessels of the myocardium, and brain. To our knowledge, A terreus endophthalmitis has not been reported previously.

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