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March 1991

Ascorbic Acid Is Cytotoxic to Dividing Human Tenon's Capsule Fibroblasts: A Possible Contributing Factor in Glaucoma Filtration Surgery Success

Author Affiliations

Detroit, Mich

Arch Ophthalmol. 1991;109(3):318-319. doi:10.1001/archopht.1991.01080030020012

To the Editor.  —We read with great interest the article by Jampel1 in the September issue of the Archives. We were pleased to see that the aqueous humor is receiving proper attention as an important factor contributing to the development of avascular cystoid conjunctival bleb following successful filtering surgery.2Jampel appropriately points out that clinical studies have demonstrated that youth, previous surgery, and anterior-segment neovascularization are characteristics that pre-dispose an eye to filtering surgery failure. We want to point out that it has been shown by Kinsey et al3 that while the aqueous ascorbate concentration is known to be some 25 times that of the plasma in adult rabbit eyes, it is not any higher than that of plasma in young rabbit eyes. Whether the same is true in humans is unknown. Lam and Lee4 have reported that the aqueous ascorbate level is much decreased in

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