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April 1991

Streptococcus sanguis Survival in K-Sol: Comparison of Gentamicin and the Fluoroquinolone Antibiotics

Author Affiliations

From the Cornea Service, University of Maryland School of Medicine, Baltimore.

Arch Ophthalmol. 1991;109(4):563-564. doi:10.1001/archopht.1991.01080040131043

• Viridans streptococci are poorly covered by gentamicin sulfate in corneal storage medium. To evaluate possible antibiotic alternatives among the newer broad-spectrum fluoroquinolone antibiotics, we compared the survival of the viridans representative Streptococcus sanguis in K-Sol with gentamicin sulfate (100 mg/L), norfloxacin (250 mg/L), ciprofloxacin lactate (250 mg/L), ofloxacin (250 mg/L), or no antibiotic. At 23°C, K-Sol with gentamicin produced a 2-log kill by 80 minutes. By comparison, only one of the others (norfloxacin) had achieved a 2-log kill by 4 hours. At 4°C, all antibiotics differed little from the control, and none was superior to gentamicin.

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