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July 1991

Microwave Cyclodestruction for Glaucoma in a Rabbit Model

Author Affiliations

From the Department of Ophthalmology, North Shore University Hospital-Cornell University Medical College, Manhasset, NY (Drs Finger, Smith, and Perry and Mr Moshfeghi); the Department of Biomedical Engineering, Tulane University, New Orleans, La (Mr Moshfeghi); the Medical Department, Brookhaven National Laboratory, Upton, NY (Dr Finger); and the Department of Ophthalmology, Cornell University Medical College (Drs Finger, Smith, and Perry).

Arch Ophthalmol. 1991;109(7):1001-1004. doi:10.1001/archopht.1991.01080070113047

• Microwave thermotherapy was used to treat experimentally induced glaucoma. Microwave-induced cyclodestruction was successful in reducing intraocular pressure in all treated glaucomatous eyes for 4 weeks. Two additional glaucomatous eyes were left untreated to serve as controls, and were noted to have persistently elevated intraocular pressures. Six additional eyes were then subjected to an equivalent treatment (50° C in five 1-minute applications), which resulted in approximately 180° of heat treatment just posterior to the corneoscleral limbus. These specimens were evaluated with light microscopy at baseline, 24 hours, and 7 days after treatment. Our clinical and histopathologic evaluations suggested that microwave thermotherapy (delivered under thermometry control) allowed for chorioretinal/ciliary body destruction that resulted in reductions of intraocular pressure in glaucomatous eyes.

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