—In response to Mr Nimoy's letter, the fundamental problem to be addressed is that some IOLAB silicone IOLs turn brown in human eyes. It is inconsequential that the IOLs do not turn brown in an in vitro situation of being heated to 45°C for 14 months. The analogy is similar to comparing apples with oranges.It is obvious that there must be some defect in either the material or manufacturing process that causes some silicone IOLs to discolor to various degrees in the human eye. This problem will only be solved by very intense research and not by speculation or insinuation that this finding is insignificant.Contrary to Mr Nimoy's response that the patient examined had "an almost imperceptible, unidentifiable imperfection at the periphery of the lens," this patient was examined by no less than five observers, all of whom concurred that the IOL was indeed brown. It
Milauskas AT. Silicone Intraocular Lens Implant Discoloration in Humans-Reply. Arch Ophthalmol. 1991;109(8):1057. doi:10.1001/archopht.1991.01080080015002
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