To the Editor.
—I read with interest the letter and reply by Gass1 and Trempe,2 respectively, on the risk of developing a macular hole. In discussing vitrectomy for early stages of macular holes, Trempe states, "... this subject is in urgent need of a randomized study. Such a study would be greatly enhanced if Dr Gass were involved in its planning." I would like to remind Trempe and the readers of the Archives that such a study is under way, with Gass to serve as a consultant, as discussed in an editorial in the Archives.3 Contrary to some pervasive ideas, I believe that, at this time, there is no evidence whatsoever that vitreous surgery is beneficial in preventing macular holes. I encourage ophthalmologists to refer appropriate patients to participating centers, where study patients with symptomatic fellow eyes with stage 1 macular holes are randomized to undergo vitrectomy vs
de Bustros S. Vitrectomy for Prevention of Macular Hole Study. Arch Ophthalmol. 1991;109(8):1057. doi:10.1001/archopht.1991.01080080015003
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